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Neuronal Traffic Jam Marks Early Alzheimers Disease

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Source : www.hhmi.org | Size : 148613

Alzheimers Disease. Early Alzheimer's disease may be . "Our hypothesis is that in familial Alzheimers. disease -- or in disorders such as Down .

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Neuronal "Traffic Jam" Marks EarlyAlzheimers Disease Early Alzheimer's disease may be precipitated by a “traffic jam” withinneurons that causes swelling and prevents proper transport of proteins andstructures in the cells, according to new studies by Howard Hughes MedicalInstitute researchers. In mouse models of Alzheimer's disease and in human brain samples frompeople with the disease, researchers observed a characteristic breakdown inneurons that appears to prevent the normal movement of critical proteins tothe communications centers of the nerve cells. In a vicious cycle, the trafficjam also could increase production of an abnormal protein that clogs neurons,leading to their failure and eventual death.

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