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NCI Cancer Bulletin

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During its May 3 meeting, the FDA Oncologic Drugs Advisory Committee reviewed data on efaproxiral (RSR13), a “radiation sensitizer” intended to be used as an adjunct to radiation therapy to make it more effective, and oblim- ersen (Genasense), part of a new class of “antisense” drugs thought to inhibit the production of proteins that protect cancer cells from treatments like ra- diotherapy and chemotherapy.Efaproxiral was being considered as an adjunct to whole brain radiation therapy (WBRT) for brain metastases in patients with breast cancer. Ap- proximately 20-30 percent of breast cancer patients develop brain metas- tases. In a 538-patient, randomized, open-label trial, the combination of WBRT and efaproxiral failed to im- prove overall survival compared to WBRT alone. A subgroup analysis not called for in the original trial de- sign, however, found that the WBRT/ efaproxiral combination nearly

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Brain Cancer

category Health » Health Brain Cancer

What is brain cancer? Brain cancer starts in the cells of the brain. 1 The brain is a soft mass of nerves (neurons) and supportive tissue (glial cells), surrounded by membranes (meninges) and protected by the skull. The brain has three main areas: • The cerebrum is the largest part.... more.

Brain Tumors Reference Summary

category Health » Health Brain Cancer

Adjuvant Therapy Radiation therapy and chemotherapy are two addi- tional treatments that may be used to control or eliminate brain tumors. Your doctor may recom- mend one or both of these therapies in addition to surgery or as an alternative to surgery. In the case of a malignant brain tumor,.... more.

Nanotechnology Tackles Brain Cancer

category Health » Health Brain Cancer

Brain cancer can be counted amongthe most deadly and intractable diseases.Often diagnosed after a patient exhibitssymptoms such as nausea, dizziness,uncharacteristic behavior changes, orparalysis, the growing mass of a braintumor will continue to squeeze out normaltissue and degrade the brain's function ifleft untreated. But treatment is elusive.Tumors may be embedded in.... more.

The Brain and Brain Cancer

category Health » Health Brain Cancer

Brain Tumors also vary according to where exactly they are found. The brain is protected by bone structures that closely encase this very important organ. As a result, any tumor in the skull (which protects the brain) can quickly interfere with its functioning. The brain is vital to life, and.... more.

Brain and Spinal Cord Tumors in Adults

category Health » Health Brain Cancer

Many types of tumors start in the brain and spinal cord (central nervous system or CNS). If you have one of these tumors, your symptoms, outlook for survival (prognosis), and treatment depend on your age, the tumor type, and the precise location of the tumor within the CNS. To help.... more.

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