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Pemetrexed Disodium Alimta For The Treatment Of Mesothelioma

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Category : » Health Mesothelioma

Source : www.nice.org.uk

treatment of mesothelioma in the short to medium term. . with demonstrable clinical efficacy in treatment of mesothelioma and as such it is .

Content Summary :

Pemetrexed disodium (Alimta™) For The Treatment of Mesothelioma The main evidence supporting the use of pemetrexed for the treatment of mesothelioma consists of a randomised study which compared a combination of pemetrexed and cisplatin (PC) with cisplatin (C) alone in patients with mesothelioma and showed that the combination regimen extended median survival by nearly 3 months (Vogelzang et al 2003). On the basis of this study the US Food and Drug Administration approved pemetrexed for the treatment of mesothelioma and it has also been licensed for this indication in Europe including the UK. Inclusion criteria included Karnofsky performance status (PS) >/= 70, corresponding to WHO or ECOG PS 0-1. Patients were excluded if they had had prior chemotherapy, a second primary malignancy, or brain metastases, or if they were unable to interrupt non-steroidal anti-inflammatory therapy which are not recommended for simultaneous use with pemetrexed because they may delay pemetrexed clearance.

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